Limb-Girdle Muscular Dystrophy (LGMD)

Definition - One of nine types of muscular dystrophy, a group of genetic, degenerative diseases primarily affecting voluntary muscles.

Cause - A mutation in any of at least 15 different genes that affect proteins necessary for muscle function.

Onset -Childhood to adulthood.

Symptoms - Weakness and wasting first affecting the muscles around the shoulders and hips (limb girdles).

Progression - Usually progresses slowly, with cardiopulmonary complications sometimes occurring in later stages of the disease.

Inheritance - Some types are autosomal dominant, meaning LGMD is inherited from one parent. Other types are autosomal recessive and occur when a faulty gene is inherited from each parent.

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